Departamento de Bologia Funcional y Ciencias de la Salud.

Area de Fisiologia.

Facultad de Biologia

Brenda V. Ferreira Nunes Rafael Durán Miguel Alfonso, Iris Machado de Oliveira Lilian R. Ferreira Faro. Evaluation of the effects and mechanisms of action of glufosinate, an organophosphate insecticide, on striatal dopamine release by using in vivo microdialysis in freely moving rats Arch Toxicol 84 (2010), 777-85.
F. Campos, M. Alfonso a, R. Durán. In vivo modulation of a7 nicotinic receptors on striatal glutamate release induced by anatoxin-A. Neurochemistry International 56: 850–855 (2010)
Iris Machado de Oliveira, Brenda Viviane Ferreira Nunes, Durán Rafael Barbosa, Alfonso Miguel Pallares, Lilian Rosana Ferreira Faro. Effects of the neonicotinoids thiametoxam and clothianidin on in vivo dopamine release in rat striatum. Toxicology Letters 192 (2010) 294–297
Rodrigues K.J.A, Santana M.B., Do Nascimento J.L.M, Picanço-Diniz D.L.W., Maues L.A.L, Santos S.N, Ferreira V.M.M, Alfonso M.Durán R., Faro L.R.F. Behavioral and biochemical effects of neonicotinoid thiamethoxam on the cholinergic system in rats. Ecotoxicology and Environmental Safety 73 (2010) 101–107
M.B. Santana, K.J.A.Rodrigues, R.Durá, M.Alfonso, L.Vidal, F.Campos, I.M. DeOliveira, L.R.F.Faro. Evaluation of the effects and mechanisms of action of flutriafol, atriazole fungicide, on striatal dopamine release by using in vivo microdialysis in freely moving rats Ecotoxicology and Environmental Safety 72 (2009) 1565–1571
Cianca RC, Barbosa RD, Faro LR, Adan LV, Gago-Martínez A, Pallares MA . Differential changes of neuroactive amino acids in samples obtained from discrete rat brain regions after systemic administration of saxitoxin. Neurochemistry International 54 (2009) 308–313
C.R.C. Cervantes, R. Durán, L.F. Faro and P.M. Alfonso. Effects of Systemic Administration of Saxitoxin on Serotonin Levels in Some Discrete Rat Brain Regions. Medicinal Chemistry, 5 (2009), 336-342
Lilian R. F. Faro, Miguel Alfonso, Rosa Cervantes and Rafael Duán. Comparative Effects of Pesticides on In Vivo Dopamine Release in Freely Moving Rats Basic & Clinical Pharmacology & Toxicology, (2009), 105, 395–400
Lucìa Vidal, Rafael Durán, Lilian R.F. Faro, Miguel Alfonso. Involvement of nicotinic and muscarinic acetylcholine receptors on striatal HgCl2-induced dopamine release in freely moving rats Toxicology Letters 178 (2008) 181–184
F. Campos, S. Rellán, R. Duran, A. Gago , L.F. Faro, M. Alfonso. Evaluation of in vivo and in vitro recovery rate of anatoxin-a through the microdialysis probe. Toxicon 52 (2008) 817–823
L.R.F. Faro, K.J.A. Rodrigues, M.B. Santana, L. Vidal, M. Alfonso, and R. Durán. Comparative effects of organic and inorganic mercury on in vivo dopamine release in freely moving rats. Brazilian Journal of Medical and Biological Research 40 (2007), 1361-1365 .
Rosa Carmina Cervantes Cianca, Miguel Alfonso Pallares, Rafael Duràn Barbosa, Lucìa Vidal Adan, J. Manuel Leao Martins, Ana Gago-Martínez. Application of precolumn oxidation HPLC method with fluorescence detection to evaluate saxitoxin levels in discrete brain regions of rats. Toxicon 49, (2007), 89–99 .
F. Campos, R. Durán, L. Vidal, L. R. F. Faro, M. Alfonso. In vivo neurochemical characterization of Anatoxin-a evoked dopamine release from striatum. J Neural Transm (2007) 114: 173–184.
Vidal, L.; Alfonso, M.; Campos , F.; Faro, L.R.F.; Cervantes, R.C., Durán R. Evaluation of the effects and mechanisms of action of mercuric chloride on striatal dopamine release by using in vivo microdialysis in freely moving rats.   Toxicology (2007) 236, 42-49.
Vidal, L., Durán, R., FARO, L.R.F., Campos, F., Cervantes, R.C., Alfonso, M . Protection from inorganic mercury effects on the in vivo dopamine release by ionotropic glutamate receptor antagonists and nitric oxide synthase inhibitors. Toxicology 238, (2007), 140-146
Faro L. R. F., Rodrigues, K. J. A., Santana, M. B., Vidal L, ALFONSO, M., Durán, R. Comparative effects of organic and inorganic mercury on the In Vivo dopamine release in freely moving rats . Brazilian Journal of Medical and Biological Research., 40: 1361-5, (2007).
Cervantes Cianca RC, Pallares MA, Durán Barbosa R,, Vidal Adan L,, Leao Martins JM,, Gago-Martinez A. Application of precolumn oxidation HPLC method with fluorescence detection to evaluate saxitoxin levels in discrete brain regions of ats. Toxicon 49 (2007), 89-99 .
Campos F, Alfonso M, Vidal L, Faro LR, Duran R. Mediation of glutamatergic receptors and nitric oxide on striatal dopamine release evoked by anatoxin-a. An in vivo microdialysis study. Eur J Pharmacol 248 ( 2006), 90-98.
Campos F, Duran R, Vidal L, Faro LR, Alfonso M. In vivo neurochemical characterization of Anatoxin-a evoked dopamine release from striatum. J Neural Transm (2007) 114, 173–184
Campos F, Duran R, Vidal L, Faro LR, Alfonso M. In vivo Effects of the Anatoxin-a on Striatal Dopamine Release . Neurochem Res. 2006. 31(4):491-501 .
L. Vidal,  M. Alfonso,  F. Campos, L. R. F. Faro,  R. C. Cervantes,  and R. Durán . Effectc of Manganese on Extracellular levels of Doapamine in rat striatum: An Analysis In vivo by Brain Microdialysis.  Neurochem. Res. 2005. 30:1147-1154 .
L. R.F. Faro, J.L.M. do Nascimento, F. Campos, L. Vidal, M. Alfonso and R.Durán. Protective effects of glutathione and Cysteine on methylmercury-induced striatal Dopamine release in vivo. Life Sciences 77, 444-451 (2005).
Alfonso M, Duran R, Campos F, Perez-Vences D, Faro LR, Arias B. Mechanisms underlying domoic acid-induced dopamine release from striatum: an in vivo microdialysis study. Neurochem Res. 2003 Oct;28(10):1487-93.
Faro LR, Duran R, Do Nascimento JL, Perez-Vences D, Alfonso M . Effects of successive intrastriatal methylmercury administrations on dopaminergic system. Ecotoxicol Environ Saf. 2003 Jun;55(2):173-7 .
Faro LR, do Nascimento JL, Alfonso M, Duran R. Protection of methylmercury effects on the in vivo dopamine release by NMDA receptor antagonists and nitric oxide synthase inhibitors. Neuropharmacology. 2002 Apr;42(5):612-8.
Faro LR, do Nascimento JL, Alfonso M, Duran R. Mechanism of action of methylmercury on in vivo striatal dopamine release. Possible involvement of dopamine transporter. Neurochem Int. 2002; 40(5):455-65.
Arufe MC, Duran R, Perez-Vences D, Alfonso M. Endogenous excitatory amino acid neurotransmission regulates thyroid-stimulating hormone and thyroid hormone secretion in conscious freely moving male rats. Endocrine. 17, (2002), 193-197.
Faro LR, do Nascimento JL, Alfonso M, Duran R. In vivo effects of inorganic mercury (HgCl(2)) on striatal dopaminergic system. Ecotoxicol Environ Saf 48, (2001), 263-267 .
Alfonso M, Duran R, Arufe MC. Effect of excitatory amino acids on serum TSH and thyroid hormone levels in freely moving rats. Horm Res. 2000;54(2):78-83.
Faro LR, do Nascimento JL, San Jose JM, Alfonso M, Duran R . Intrastriatal administration of methylmercury increases in vivo dopamine release. Neurochem Res. 2000 ;25(2):225-229.
Quintela BA, Duran R, Alfonso M. Mediation of ionotropic glutamate receptors in domoic acid-induced striatal dopamine release in rats. Eur J Pharmacol. 2000 401(2):173-177.
Arufe MC, Beckett GJ, Duran R, Alfonso M. Effect of okadaic acid and calyculin-A, two protein phosphatase inhibitors, on thyrotropin-stimulated triiodothyronine secretion in cultured sheep thyroid cells. Endocrine. 1999 11(3):235-40.
Arias B, Duran R, Alfonso M. In vivo release of dopamine and its metabolites from rat striatum in response to domoic acid. Neurochem Res. 1998 23(12):1509-14.
Alfonso M, Arufe MC, Duran R. Validation of an EIA kit for determination of total thyroid hormones in rat serum. Effects of different anaesthetics. J Physiol Biochem. 1998 54(1):15-21.
Faro LR, do Nascimento JL, Alfonso M, Duran R. Acute administration of methylmercury changes in vivo dopamine release from rat striatum. Bull Environ Contam Toxicol. 1998 60(4):632-8. abstract no available.
Faro LR, Duran R, do Nascimento JL, Alfonso M, Picanco-Diniz CW. Effects of methyl mercury on the in vivo release of dopamine and its acidic metabolites DOPAC and HVA from striatum of rats. Ecotoxicol Environ Saf. 1997 38(2):95-8.
Arufe MC, Arias B, Duran R, Alfonso M. Effects of domoic acid on serum levels of TSH and thyroid hormones. Endocr Res. 1995 Aug;21(3):671-80.
Arias B, Arufe M, Alfonso M, Duran R. Effect of domoic acid on metabolism of 5-hydroxytryptamine in rat brain. Neurochem Res. 1995; 20(4):401-4.
Duran R, Arufe MC, Arias B, Alfonso M. Effect of domoic acid on brain amino acid levels. Rev Esp Fisiol. 1995 Mar;51(1):23-7.
Alfonso M, Duran R, Duarte CB, Ferreira IL, Carvalho AP. Domoic acid induced release of [3H]GABA in cultured chick retina cells. Neurochem Int. 1994 Mar;24(3):267-274.
Alfonso M, Duran R, Marco J. Ethanol-induced alterations in gonadotrophins secretion during the estrous cycle of rats. Alcohol Alcohol. 1993 28(6):667-674.
.Alfonso M, Duran R, Marco J. In vitro effect of ethanol on LH and FSH secretion by pituitary glands of female rats. Endocr Res. 1993;19(2-3):175-86
Alfonso M, Marco J, Balvis IA, Pazo JA. Direct action of ethanol on pituitary prolactin secretion in vitro. Rev Esp Fisiol. 1991 Sep;47(3):133-40.
Parafita MA, Pazo JA, Alfonso M, Beiras E. Antigenical alterations of hepatocyte membrane in rats after long-term administration of ethanol and carbon tetrachloride. Drug Alcohol Depend. 1989 23(2):177-9.
Alfonso M, Marco J, Balvis IA, Venta R. Changes in the prolactin levels after administration of ethanol in diestrus. Rev Esp Fisiol. 1989; 45 Suppl:79-86.
Marco J, Alfonso M, Lafuente A, Alonso J, Cousillas G. Effect o f progesterone and estradiol on the regulation of pulsatile secretion of LH in the various phases of the estrous cycle of rats. Rev Esp Fisiol. 1989; 45 Suppl: 65-77.
Aldegunde M, Duran R, Alfonso M, Miguez I, Veira J. Effect of long-term pinealectomy on serum LH levels and on cerebral serotonin metabolism in adult male rats. Rev Esp Fisiol. 1987;43(3):351-4.
M. Parafita, J.A. Pazo, M. ALFONSO y E. Beiras. Antigenical alterations of hepatocytemembrane in rats after long-term administration of ethanol and carbon tetraclhoride. Drug and Alcohol Dependence 23, 177-179 (1989)
I. Miguez, M. Aldegunde y M. ALFONSO.  Efecto de la administración intraperitoneal de GABA sobre los niveles cerebrales de aminas biógenas y hormonas gonadotrópicas (LH y FSH) en ratas macho adultas.  Boletín de la Academia Gallega de las Ciencias 6, 13-19 (1987) .
M. Aldegunde, R. Durán, M. ALFONSO, I. Miguez y J. Veira . Effect of long-term pinealectomy on serum LH levels and on cerebral serotonin metabolism in adult male rats . Revista Española de Fisiología 43, 351-354 (1987)		.
M. A. Parafita, E. Beiras, J.A. Pazo, M. ALFONSO y E. Barrio.  Aspectos metodológicos de la perfusión hepática y del aislamiento de los hepatocitos. Gastroenterología hepática, 9, 36-48 (1986).
M.A Parafita, J. A. Pazo. M. ALFONSO y M. Aldegunde .  Oxidative capacity  and ethanol. A in vivo study on hepatocytes and some brain regions of the female rat . Drug and Alcohol Dependence 15, 73-80 (1985).
M. ALFONSO, M. A. Parafita, M. J. Mancebo y J. Marcó. Further evidence for effects of ethanol on gonadotrophins and prolactin in female rats. General Pharmacology. 16, 215-218 (1985).
M.A. Parafita, M. ALFONSO, J. A. Pazo y E. Beiras. Cambios en la morfología ultraestructural de los hepatocitos aislados de ratas en respuesta al Carbaryl. Acta Científica Compostelana 21, 255-272 (1984).
M.J. Mancebo, M. ALFONSO, R. Durán y J. Marcó.  Effects of ethanol administration in a preovulatory period on hypothalamic-Pituitry- Gonadal axis in female rats . Research Comunication in Substances of Abuse 5, 221-231. (1985).
J. Marcó, M. A. Parafita, M. ALFONSO y J. Espinosa . Changes in serum LH and FSH following preovulatory administratión of ethanol in rats. Drug and Alcohol Dependence 14, 215-218 (1984).
J . Marcó, M.A. Parafita,, M. ALFONSO,y J. C. Perez. Stimulation of prolactin release by ethanol administered in preovulatory periods .  IRCS Medical Science 12, 152-153 (1984).

PUBLICACION Y EDICIÓN DE LIBROS

El mercurio como contaminante ambiental y agente neurotóxico.

Editado por Lilian Ferreira Faro, Rafael Durán Barbosa y Miguel Alfonso Pallares.

Servicio de Publicaciones Universidad de Vigo, 2010.

ISBN:978-84-8158-500-1

• Capitulo 7. Lilian Ferreira Faro, Rafael Durán Barbosa y Miguel Alfonso Pallares: “ Estudios in vivo de los efectos del mercurio sobre el sistema dopaminérgico” . pp143-167
• Capitulo 8. Lilian Ferreira Faro, Rafael Durán Barbosa y Miguel Alfonso Pallares: “ Mecanismos neuroquímicos de acción del mercurio sobre la liberaciónde dopamina”. Pp169-191.
• Capitulo 9. Lilian Ferreira Faro, Rafael Durán Barbosa y Miguel Alfonso Pallares: “ Protección de los efectos del mercurio”. 193-218.

Neurotransmisión y Endocrinología.

Editado por M. Alfonso, M.A. Andrade, R. Durán y R.V. Garcia-Mayor.

Universidad de Vigo, Año 1992.

ISBN 84-640-3928-3 .

• Capitulo 1. R. Durán y M. Alfonso. Introducción a la Neurotransmisión y los neurotransmisores . Pp 9-22
• Capitulo 2- R. Durán y M. Alfons o. "Segundos mensajeros". Pp 21- 30.
• Capitulo 6. M . Alfonso y R. Durán. "Principios generales de endocrinología". P p 75-86.
• Capitulo 7. M . Alfonso y R. Durán "Hormonas hipotalámicas-hipofisotrópicas". Pp 87-98.

Facultad de Biología. Bloque B. 3ª Planta. Despacho 18. Campus As Lagoas- Marcosende. 36310 Vgo.

Telefono: 986812391 / 986811996. e-mail: pallares@uvigo.es